29 Mar Phase III trials ‘hit a home run’ in advanced endometrial cancer

Adding immunotherapy will change frontline treatment, experts say.

By Mike Bassett, MedPage Today

Immunotherapy combined with standard chemotherapy significantly improved progression-free survival (PFS) in patients with advanced or recurrent endometrial cancer, according to results from two randomized phase III trials presented at the Society of Gynecologic Oncologyopens in a new tab or window (SGO) annual meeting.

In the NRG-GY018 trialopens in a new tab or window, the PFS rates were estimated to be 74% with the addition of pembrolizumab (Keytruda) to paclitaxel plus carboplatin and 38% with placebo at 12 months among patients with mismatch repair-deficient (dMMR) disease (HR 0.30, 95% CI 0.19-0.48, P<0.001), reported Ramez N. Eskander, MD, of the University of California San Diego.

Among patients with mismatch repair-proficient (pMMR) disease, the median PFS was 13.1 months in the pembrolizumab group and 8.7 months in the placebo group (HR 0.54, 95% CI 0.41-0.71, P<0.001).

In the RUBY trialopens in a new tab or window, the estimated PFS at 24 months was 61.4% with the addition of dostarlimab (Jemperli) to paclitaxel-carboplatin compared with 15.7% with placebo in patients with dMMR, microsatellite instability-high (MSI-H) tumors (HR 0.28, 95% CI 0.16-0.50, P<0.001), reported Mansoor R. Mirza, MD, of Copenhagen University Hospital in Denmark. Read more …